Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl Gly-Cysteine(Psi(Dmp,H)Pro)-Oh is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is critical for introducing specific conformational constraints and enhancing the metabolic stability of peptide-based drug candidates. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel therapeutics, including protease inhibitors and peptide hormones.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating pseudoproline dipeptide mimetics, facilitating difficult couplings and improving peptide solubility during synthesis.
• Medicinal Chemistry & Drug Discovery: For the design and synthesis of constrained peptide analogs with enhanced bioavailability and target selectivity.
• Protease Inhibitor Development: Used in creating potent inhibitors for enzymes like caspases or viral proteases by mimicking transition states.
• Peptide Library Construction: Enables the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation & Probe Development: Serves as a modified amino acid for creating labeled peptides for diagnostic or imaging applications.
• Academic Research: For studying peptide folding, stability, and structure-activity relationships (SAR).

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl Gly-Cysteine(Psi(Dmp,H)Pro)-Oh
CAS No.	1926163-05-4
Molecular Formula	C26H28N2O6S
Molecular Weight	496.58 g/mol
Synonyms	Fmoc-Cys(ψMe,Mepro)-OH; Fmoc-Cys(ψMe,Mepro)-OH; Fmoc-Cysteine(ψMe,Meproline)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-L-cysteine; Fmoc-Cys(Dmp)-OH; Pseudoproline dipeptide derivative; Fmoc-protected cysteine pseudoproline; Non-natural amino acid building block
EINECS	Contact for details

Quality Control

Every batch of our (9H-Fluoren-9-Yl)Methoxy]Carbonyl Gly-Cysteine(Psi(Dmp,H)Pro)-Oh is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as chiral purity and residual solvent levels. Our quality commitment aligns with the standards expected for pharmaceutical R&D and GMP-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For optimal performance, store under an inert atmosphere such as argon or nitrogen after initial opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.