Description

(R)-2-((6-(3-Aminopiperidin-1-Yl)-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Methyl)-4-Fluorobenzoic Acid is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. Its precise stereochemistry and functional groups make it a critical building block for the synthesis of advanced antiviral therapeutics. This compound is essential for research and development laboratories and production facilities focused on next-generation HIV and antiviral treatments.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral drug discovery.
• Antiviral Drug Development: Serves as a core structural component in the R&D of new chemical entities targeting HIV and other retroviruses.
• Process Chemistry & Scale-Up: Used in process optimization and pilot-scale manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in enzymatic and binding studies to understand mechanisms of reverse transcriptase inhibition.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis: A starting point for the custom synthesis of structurally related analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(R)-2-((6-(3-Aminopiperidin-1-Yl)-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Methyl)-4-Fluorobenzoic Acid
CAS No.	1917324-15-2
Molecular Formula	C19H23FN4O4
Molecular Weight	390.41 g/mol
Synonyms	(R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzoic acid; 4-Fluoro-2-[[(6R)-6-(3-amino-1-piperidinyl)-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzoic acid; (R)-4-Fluoro-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzoic acid; NNRTI Intermediate 1917324-15-2; (R)-enantiomer of fluorobenzoic acid uracil derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (R)-2-((6-(3-Aminopiperidin-1-Yl)-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)Methyl)-4-Fluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.