Description

2-(2,4,6-Trimethylphenyl)-2,2-Difluoroethan-1-Ol is a specialized fluorinated organic building block characterized by a difluoroethanol moiety attached to a mesitylene core. This compound matters as a high-value intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs), where its unique fluorine substitution pattern can impart critical properties like metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Key fluorinated intermediate in the research and development of novel pharmaceutical compounds, particularly for introducing difluoroethyl motifs.
• Building block for the synthesis of agrochemicals, where fluorine atoms can enhance biological activity and environmental stability.
• Precursor in the development of specialty polymers and advanced materials requiring specific fluorine-based properties.
• Used in organic synthesis and medicinal chemistry for structure-activity relationship (SAR) studies.
• Intermediate for creating ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Starting material for the preparation of fluorinated liquid crystals or electronic materials.

Basic Information

Product Name	2-(2,4,6-Trimethylphenyl)-2,2-Difluoroethan-1-Ol
CAS No.	1895405-54-5
Molecular Formula	C11H14F2O
Molecular Weight	200.23 g/mol
Synonyms	2,2-Difluoro-2-(2,4,6-trimethylphenyl)ethanol; 1-(2,4,6-Trimethylphenyl)-2,2-difluoroethan-1-ol; α,α-Difluoro-2,4,6-trimethylbenzeneethanol; 2-(Mesityl)-2,2-difluoroethanol; 2,2-Difluoro-1-(mesityl)ethanol; DFME; Mesityl-difluoroethanol
EINECS	Contact for details

Quality Control

Our 2-(2,4,6-Trimethylphenyl)-2,2-Difluoroethan-1-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding applications in GMP-intermediate synthesis and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its chemical nature as a fluoride/strong alkali-sensitive compound, keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.