Description

2,4-Pyrimidinediamine, N4-Cyclopropyl-N2-(3,4-Dimethoxyphenyl)-5-(Trifluoromethyl)- is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethylated pyrimidine core. This compound is specifically engineered for its role in the synthesis of novel, targeted therapeutic agents, offering researchers and manufacturers a critical building block for drug discovery and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers engaged in creating next-generation small molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel kinase inhibitors and other targeted small molecule therapeutics.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical scaffold in the multi-step synthesis of potential active drug substances.
• Chemical Biology Probes: Employed in the creation of molecular probes to study specific biological pathways and protein functions.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes in pilot plants and commercial manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis projects.

Basic Information

Product Name	2,4-Pyrimidinediamine, N4-Cyclopropyl-N2-(3,4-Dimethoxyphenyl)-5-(Trifluoromethyl)-
CAS No.	1884222-74-5
Molecular Formula	C16H17F3N4O2
Molecular Weight	354.33 g/mol
Synonyms	N4-Cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine; 5-(Trifluoromethyl)-N4-cyclopropyl-N2-(3,4-dimethoxyphenyl)pyrimidine-2,4-diamine; 2,4-Diamino-N-cyclopropyl-5-(trifluoromethyl)-N-(3,4-dimethoxyphenyl)pyrimidine; Cyclopropyl-[2-[(3,4-dimethoxyphenyl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amine
EINECS	Contact for details

Quality Control

Every batch of 2,4-Pyrimidinediamine, N4-Cyclopropyl-N2-(3,4-Dimethoxyphenyl)-5-(Trifluoromethyl)- is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), identity confirmation, and impurity profiles is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.