Description

3-Ethoxy-5-(Trifluoromethyl)Phenol is a versatile fluorinated phenolic intermediate of significant interest in advanced organic synthesis. Its unique structure, featuring both an ethoxy group and a trifluoromethyl substituent on the aromatic ring, makes it a valuable building block for creating complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms can dramatically alter biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and stability.
• Polymer Modification: Acts as a functional monomer or additive to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, etherifications, and other transformations to construct complex aromatic systems in academic and industrial research.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments that offer improved lightfastness and unique color properties.

Basic Information

Product Name	3-Ethoxy-5-(Trifluoromethyl)Phenol
CAS No.	1881320-95-1
Molecular Formula	C9H9F3O2
Molecular Weight	206.16 g/mol
Synonyms	5-(Trifluoromethyl)-3-ethoxyphenol; 3-Ethoxy-5-(trifluoromethyl)benzenol; 1-Ethoxy-3-hydroxy-5-(trifluoromethyl)benzene; m-Ethoxy-α,α,α-trifluoro-m-cresol; Phenol, 3-ethoxy-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-Ethoxy-5-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.