Description

2-Amino-4-Chloro-N2-Pivaloyl-7-[2-Deoxy-3,5-Di-o-(4- Methylbenzoyl)--D-Ribofuanosyl]-7H-Pyrrolo[2,3-D]Pyrimidine is a sophisticated nucleoside analog building block, a key intermediate in the synthesis of novel therapeutic agents. Its complex structure, featuring a modified pyrrolo[2,3-d]pyrimidine core, is designed for targeted drug discovery, particularly in oncology and antiviral research. This high-purity intermediate is essential for pharmaceutical R&D teams and fine chemical manufacturers developing next-generation nucleoside-based pharmaceuticals.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside analog drugs targeting viral infections and specific cancers.
• Antiviral Drug Development: Used in research and production of potential therapeutics for a range of DNA and RNA viruses.
• Oncology Research: Serves as a precursor in the development of antimetabolite chemotherapeutic agents that interfere with DNA synthesis in rapidly dividing cells.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand cellular processes and nucleotide metabolism.
• Process Chemistry & Scale-Up: Used by fine chemical manufacturers for the kilogram-scale production of advanced active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs developing proprietary compounds for clients.

Basic Information

Product Name	2-Amino-4-Chloro-N2-Pivaloyl-7-[2-Deoxy-3,5-Di-o-(4- Methylbenzoyl)--D-Ribofuanosyl]-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	1878120-03-6
Molecular Formula	C₃₃H₃₄ClN₅O₇
Molecular Weight	648.10 g/mol
Synonyms	4-Chloro-2-(pivalamido)-7-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine; 2-Amino-4-chloro-7-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine N2-pivalate; 7-(2-Deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-ribofuranosyl)-4-chloro-2-(pivalamido)-7H-pyrrolo[2,3-d]pyrimidine; Nucleoside Analog Intermediate 1878120-03-6; Chlorinated Pyrrolopyrimidine Riboside Ester; Pivaloyl-protected Nucleoside Building Block
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.