Description

(Biotinyl-Cys1,Lys(Biotinyl)18)-Calcitonin (Human) CAS NO 1872440-39-5 is a chemically modified, biotinylated analog of the human calcitonin peptide hormone. This derivative is engineered for high-affinity binding to avidin or streptavidin, making it an essential tool in advanced biochemical research and diagnostic assay development. It is primarily utilized by pharmaceutical researchers, biotech companies, and diagnostic manufacturers for applications requiring precise molecular tagging and detection.

Application

• Bioconjugation & Probe Development: Serves as a critical reagent for creating biotin-streptavidin based probes for immunoassays (ELISA, Western Blot) and biosensors.
• Targeted Drug Delivery Research: Used in preclinical studies to investigate receptor-mediated delivery systems, leveraging the calcitonin receptor pathway.
• Protein-Protein Interaction Studies: Facilitates the study of calcitonin receptor interactions and signaling pathways through pull-down assays and affinity purification.
• Diagnostic Kit Manufacturing: Incorporated as a key component in the production of high-sensitivity diagnostic kits for bone metabolism disorders.
• Cell Imaging & Microscopy: Enables specific labeling and visualization of calcitonin receptors in cellular and tissue samples using fluorescence microscopy.
• Peptide Therapeutics Research: Acts as a model compound in the research and development of novel, targeted peptide-based therapeutics.

Basic Information

Product Name	(Biotinyl-Cys1,Lys(Biotinyl)18)-Calcitonin (Human)
CAS No.	1872440-39-5
Molecular Formula	C₁₆₀H₂₄₆N₄₄O₄₅S₃
Molecular Weight	3607.1 g/mol (monoisotopic)
Synonyms	Biotinylated Human Calcitonin; Biotin-Calcitonin (Human); Calcitonin Human, Biotinylated; Biotinyl-Cys1,Lys(Biotinyl)18-Calcitonin; H-Cys(ACM)-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys(Biotinyl)-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bond: Cys1-Cys7); Biotin-Labeled Calcitonin; Calcitonin, human, biotin conjugate
EINECS	Contact for details

Quality Control

Our (Biotinyl-Cys1,Lys(Biotinyl)18)-Calcitonin (Human) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specification parameters to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Biotinylation (MS)	Confirmed at specified residues
Peptide Content (Amino Acid Analysis)	≥ 80%
Water Content (Karl Fischer)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.