Description

Dnp-(Leu421)-Collagen Type Viii α1 Chain (419-426) Amide (Human, Mouse) Trifluoroacetate Salt is a synthetic peptide fragment derived from the α1 chain of Collagen Type VIII, specifically modified with a dinitrophenyl (Dnp) group at the Leu421 position. This compound is a critical research tool for studying angiogenesis, cell-matrix interactions, and the role of specific collagen epitopes in vascular biology and related pathologies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cardiovascular disease, tissue engineering, and autoimmune disorder research. The product is supplied as a high-purity trifluoroacetate salt to ensure stability and solubility in aqueous buffers.

Application

• Biomedical Research: Used as a specific antigen or epitope in studies investigating the role of Collagen Type VIII in angiogenesis, atherosclerosis, and Descemet's membrane formation.
• Immunoassay Development: Serves as a coating antigen or standard in ELISA (Enzyme-Linked Immunosorbent Assay) for detecting and quantifying autoantibodies in research related to autoimmune diseases.
• Antibody Production & Characterization: Acts as an immunogen for generating and screening monoclonal or polyclonal antibodies against a defined collagen epitope.
• Cell Adhesion & Signaling Studies: Applied in in vitro assays to study integrin-mediated cell adhesion, migration, and signaling pathways triggered by specific collagen sequences.
• Tissue Engineering Research: Investigated as a bioactive peptide component in scaffolds to modulate endothelial cell behavior and promote specific vascular tissue regeneration.

Basic Information

Product Name	Dnp-(Leu421)-Collagen Type Viii α1 Chain (419-426) Amide (Human, Mouse) Trifluoroacetate Salt
CAS No.	1872435-02-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DNP-Collagen VIII (419-426); Dnp-Leu421-Collagen VIII α1 (419-426) amide; Collagen Type VIII Alpha 1 Chain Peptide (419-426), Dnp-Leu421-; (Human, Mouse) Collagen VIII Peptide Fragment; Angiogenesis Research Peptide; TFA Salt of Collagen VIII Derived Peptide; Dinitrophenyl-labeled Collagen Peptide; Synthetic Collagen Epitope
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Dnp-(Leu421)-Collagen Type Viii α1 Chain (419-426) Amide (Human, Mouse) Trifluoroacetate Salt undergoes rigorous analytical testing, including reversed-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, amino acid analysis, and other critical parameters. Our quality commitment ensures material consistency and reliability for your sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to keep the lyophilized powder under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Conforms to theoretical composition
Solubility	Soluble in water, DMSO, or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.