Description

2-(Difluoromethoxy)-4-Fluoro-5-Nitroaniline is a specialized aromatic amine derivative, distinguished by its unique difluoromethoxy and nitro substituents, which make it a valuable building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific fluorine substitution pattern is critical for modulating biological activity and metabolic stability. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical and agrochemical industries seeking to create novel, high-performance molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorinated compounds for enhanced bioavailability and target specificity.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and advanced organic electronic materials due to its unique electronic properties imparted by the fluorine and nitro groups.
• Dye and Pigment Intermediate: Functions as a starting material for synthesizing complex, color-fast dyes and specialty pigments.
• Cross-Coupling Reactions: The aniline functionality makes it a suitable substrate for palladium-catalyzed cross-coupling reactions, enabling the construction of complex biaryl structures.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom manufacturers for client-specific synthesis projects and scale-up development.

Basic Information

Item	Detail
Product Name	2-(Difluoromethoxy)-4-Fluoro-5-Nitroaniline
CAS No.	1865729-77-6
Molecular Formula	C7H5F3N2O3
Molecular Weight	222.12 g/mol
Synonyms	4-Fluoro-5-nitro-2-(difluoromethoxy)aniline; 2-Amino-4-fluoro-5-nitro-1-(difluoromethoxy)benzene; 5-Nitro-2-(difluoromethoxy)-4-fluoroaniline; 1-Amino-2-(difluoromethoxy)-4-fluoro-5-nitrobenzene; 1865729-77-6; Aniline, 2-(difluoromethoxy)-4-fluoro-5-nitro-; DFM-F-Nitroaniline
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-4-Fluoro-5-Nitroaniline is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the exacting standards required for pharmaceutical and agrochemical research and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.