Description

6-Benzyl-2,4-Dichloro-8,8-Difluoro-5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1864059-82-4. This compound is a critical building block in modern medicinal chemistry, valued for its complex heterocyclic structure which serves as a key scaffold in drug discovery programs. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in oncology and targeted disease areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Oncology Drug Development: Serves as a building block for potential kinase inhibitors and other targeted cancer therapies.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthetic routes for clients.
• Academic Research: Employed in university laboratories for investigating novel synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	6-Benzyl-2,4-Dichloro-8,8-Difluoro-5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine Hydrochloride
CAS No.	1864059-82-4
Molecular Formula	C₁₆H₁₄Cl₂F₂N₃·HCl
Molecular Weight	404.67 g/mol (Free base: 368.21 g/mol)
Synonyms	6-Benzyl-2,4-dichloro-8,8-difluoro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine HCl; 6-Benzyl-2,4-dichloro-8,8-difluoro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride; 1864059-82-4; Pyrido[4,3-d]pyrimidine, 6-(phenylmethyl)-2,4-dichloro-8,8-difluoro-5,6,7,8-tetrahydro-, hydrochloride (1:1); 6-(Phenylmethyl)-2,4-dichloro-8,8-difluoro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 6-Benzyl-2,4-Dichloro-8,8-Difluoro-5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine Hydrochloride is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.