Description

2-[4-(Trifluoromethoxy)Phenyl]Pyrimidine-4-Carboxylic Acid is a high-value, multifunctional heterocyclic building block designed for advanced chemical synthesis. Its core value lies in the strategic combination of a pyrimidine-carboxylic acid moiety and a trifluoromethoxy-substituted phenyl ring, offering versatile reactivity and unique physicochemical properties for molecular design. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of small molecule drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and liquid crystals with tailored electronic properties.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization due to its modifiable carboxylic acid and aromatic systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses producing complex, fluorinated organic molecules for client-specific projects.

Basic Information

Product Name	2-[4-(Trifluoromethoxy)Phenyl]Pyrimidine-4-Carboxylic Acid
CAS No.	1864059-55-1
Molecular Formula	C12H7F3N2O3
Molecular Weight	284.19 g/mol
Synonyms	4-Pyrimidinecarboxylic acid, 2-[4-(trifluoromethoxy)phenyl]-; 2-(4-(Trifluoromethoxy)phenyl)pyrimidine-4-carboxylic acid; 2-(4-Trifluoromethoxyphenyl)pyrimidine-4-carboxylic acid; 1864059-55-1; 2-(4-(Trifluoromethoxy)phenyl)-4-pyrimidinecarboxylic acid; 2-(4-Trifluoromethoxyphenyl)-4-pyrimidinecarboxylic acid; 2-[4-(Trifluoromethoxy)phenyl]-4-pyrimidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 2-[4-(Trifluoromethoxy)Phenyl]Pyrimidine-4-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or cGMP starting material requirements. Our quality system is designed to deliver consistent purity and reliable supply for critical development and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.