Description

Z-D-Lys(Fmoc)-Oh is a protected amino acid derivative, specifically the Nε-Fmoc-protected D-lysine, essential for solid-phase peptide synthesis (SPPS). This compound matters because it provides orthogonal protection, allowing for the selective deprotection and elongation of peptide chains to create complex biomolecules with high precision. It is critically needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, peptidomimetics, and biochemical probes. Its high purity and reliable performance are fundamental for ensuring reproducible results in advanced synthetic chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of D-lysine residues into peptide sequences.
• Pharmaceutical Research & Development: For the synthesis of novel peptide-based drug candidates, including antimicrobial and anticancer peptides.
• Bioconjugation: Utilized to introduce a reactive amine handle (after Fmoc deprotection) for linking peptides to other molecules, dyes, or solid surfaces.
• Combinatorial Chemistry: Serves as a critical component in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Tool Development: Used in creating labeled peptides, affinity tags, and substrates for enzyme studies.
• Academic Research: Fundamental studies in organic chemistry, peptide structure-activity relationships, and molecular biology.

Basic Information

Product Name	Z-D-Lys(Fmoc)-Oh
CAS No.	1864003-01-9
Molecular Formula	C30H32N2O6
Molecular Weight	516.59 g/mol
Synonyms	Nε-Fmoc-Nα-Z-D-lysine; D-Lysine, N2-[(phenylmethoxy)carbonyl]-N6-(9H-fluoren-9-ylmethoxycarbonyl)-; Fmoc-D-Lys(Z)-OH; Z-D-Lys(Fmoc)-OH; Nα-Carbobenzoxy-Nε-9-fluorenylmethoxycarbonyl-D-lysine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((benzyloxy)carbonyl)amino)hexanoic acid; Nα-Cbz-Nε-Fmoc-D-lysine; Nα-Z-Nε-Fmoc-D-lysine
EINECS	Contact for details

Quality Control

Our Z-D-Lys(Fmoc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical research and development. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm the D-configuration. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.