Description

D-2-Hydroxykynurenine is a specific enantiomer of the tryptophan metabolite 2-hydroxykynurenine, identified by CAS NO 1858273-27-4. This compound is of significant interest in biochemical research and pharmaceutical development due to its role in the kynurenine pathway, which is central to neurochemistry and immunology. It is primarily sought by researchers and manufacturers in the life sciences sector for applications in neuroscience, metabolic studies, and as a reference standard or synthetic intermediate for novel therapeutics.

Application

• Biochemical Research: Critical for studying the kynurenine pathway, neuroinflammation, and neurodegenerative disease mechanisms.
• Pharmaceutical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in drug discovery.
• Metabolite Analysis: Employed in mass spectrometry and HPLC assays to quantify metabolic changes in biological samples.
• Enzyme Substrate: Serves as a substrate for research on enzymes like kynureninase within the tryptophan degradation pathway.
• Precursor Synthesis: Acts as a chiral building block for the synthesis of more complex neuroactive compounds and potential drug candidates.
• Cell Culture & In Vitro Studies: Used to modulate metabolic pathways in cell-based assays to investigate cellular responses and signaling.

Basic Information

Product Name	D-2-Hydroxykynurenine
CAS No.	1858273-27-4
Molecular Formula	C10H12N2O4
Molecular Weight	224.21 g/mol
Synonyms	(2R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid; D-2-HK; D-2-Hydroxykynurenine; (R)-2-Hydroxykynurenine; (R)-2-Amino-4-(2-aminobenzoyl)butanoic acid; D-α-Amino-2-aminobenzoylpropionic acid; D-Form of 2-Hydroxykynurenine
EINECS	Contact for details

Quality Control

Our D-2-Hydroxykynurenine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all test results to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.