Description

4-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]Pyrimidine-2-Thiol is a high-value, heterocyclic organic compound featuring a pyrimidine-thiol core linked to a substituted pyridine ring. This structure is critical for its role as a versatile advanced pharmaceutical intermediate and building block in modern synthetic chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in kinase inhibitor research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides with enhanced efficacy.
• Material Science Research: Serves as a precursor for creating specialized ligands and functional organic materials.
• Chemical Biology Probes: Employed in the design of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex molecules under cGMP conditions.

Basic Information

Product Name	4-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]Pyrimidine-2-Thiol
CAS No.	1858250-86-8
Molecular Formula	C11H8F3N3S
Molecular Weight	271.26 g/mol
Synonyms	2-Mercapto-4-[2-methyl-6-(trifluoromethyl)-3-pyridinyl]pyrimidine; 4-(2-Methyl-6-(trifluoromethyl)pyridin-3-yl)pyrimidine-2-thiol; 2-Pyrimidinethiol, 4-[2-methyl-6-(trifluoromethyl)-3-pyridinyl]-; 4-(2-Methyl-6-(trifluoromethyl)-3-pyridyl)pyrimidine-2-thiol; 1858250-86-8
EINECS	Contact for details

Quality Control

Our production of 4-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]Pyrimidine-2-Thiol adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized; prolonged exposure to air should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.