Description

6,8-Dibromo-5-Chloroquinazolin-4-Ol is a high-purity, multi-halogenated quinazolinone derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in providing a versatile and reactive scaffold for the synthesis of novel, biologically active compounds, particularly in medicinal chemistry research. This product is essential for R&D chemists and process development scientists in the pharmaceutical and agrochemical industries who are developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Agrochemical Development: Serves as a precursor in the research and development of new herbicides and fungicides.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study enzyme function and biological pathways.
• Organic Synthesis: A versatile halogenated intermediate for further functionalization via cross-coupling and nucleophilic substitution reactions.

Basic Information

Product Name	6,8-Dibromo-5-Chloroquinazolin-4-Ol
CAS No.	1858241-98-1
Molecular Formula	C8H3Br2ClN2O
Molecular Weight	362.38 g/mol
Synonyms	4-Hydroxy-6,8-dibromo-5-chloroquinazoline; 5-Chloro-6,8-dibromo-4-quinazolinol; 6,8-Dibromo-5-chloro-4(3H)-quinazolinone; 5-Chloro-6,8-dibromoquinazolin-4-ol; 6,8-Dibromo-5-chloroquinazolin-4(3H)-one; 1858241-98-1
EINECS	Contact for details

Quality Control

Our 6,8-Dibromo-5-Chloroquinazolin-4-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound should be kept under an inert atmosphere if long-term stability is a concern. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.