Description

2'-Fluoro-4'-Methyl-3'-(Trifluoromethyl)Acetophenone is a high-purity fluorinated acetophenone derivative, a critical building block in advanced organic synthesis. Its unique trifluoromethyl and fluoro substituents make it a valuable intermediate for creating molecules with enhanced metabolic stability and lipophilicity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine motifs improve biological activity.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its aromatic and fluorinated structure.
• Chemical Research & Development: A versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2'-Fluoro-4'-Methyl-3'-(Trifluoromethyl)Acetophenone
CAS No.	1824274-63-6
Molecular Formula	C10H6F4O
Molecular Weight	218.15 g/mol
Synonyms	1-(2-Fluoro-4-methyl-3-(trifluoromethyl)phenyl)ethan-1-one; 2-Fluoro-4-methyl-3-(trifluoromethyl)acetophenone; 2'-Fluoro-4'-methyl-3'-(trifluoromethyl)acetophenone; 3-(Trifluoromethyl)-2-fluoro-4-methylacetophenone; 2-Fluoro-α,α,α,4-tetramethylacetophenone; 1-[2-Fluoro-4-methyl-3-(trifluoromethyl)phenyl]ethanone; CAS 1824274-63-6
EINECS	Contact for details

Quality Control

We maintain rigorous quality control protocols for all our fluorinated intermediates. Each batch of 2'-Fluoro-4'-Methyl-3'-(Trifluoromethyl)Acetophenone is analyzed using advanced techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.