Description

2-(4-Chloro-2-Fluorophenyl)-2,2-Difluoroethan-1-Ol is a high-value fluorinated aromatic building block characterized by its unique difluoroethanol moiety attached to a substituted phenyl ring. This compound is critical for researchers and manufacturers seeking to introduce specific fluorine patterns into complex molecules, which can dramatically alter their physical, chemical, and biological properties. It is primarily utilized in the development of advanced pharmaceuticals, agrochemicals, and functional materials where precise fluorination is required for activity, stability, or bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug discovery programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where fluorination enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes, improving performance and durability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Fluorine Chemistry Research: An essential reagent for academic and industrial R&D focused on exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	2-(4-Chloro-2-Fluorophenyl)-2,2-Difluoroethan-1-Ol
CAS No.	1824017-29-9
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	2,2-Difluoro-2-(4-chloro-2-fluorophenyl)ethanol; 1-(4-Chloro-2-fluorophenyl)-2,2-difluoroethan-1-ol; 4-Chloro-2-fluoro-α,α-difluorobenzeneethanol; (4-Chloro-2-fluorophenyl)difluoromethyl carbinol; α,α-Difluoro-4-chloro-2-fluorobenzeneethanol; 2-(4-Chloro-2-fluorophenyl)-2,2-difluoroethanol
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Chloro-2-Fluorophenyl)-2,2-Difluoroethan-1-Ol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.