Description

2-(4-Chloro-3-Fluorophenyl)-2,2-Difluoroethan-1-Ol is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound is critical for introducing the difluoroethanol moiety into complex molecular architectures, significantly influencing the physicochemical and biological properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal Materials: Serves as a fluorinated component in the production of advanced liquid crystals for display technologies, improving dielectric anisotropy and response times.
• Polymer Science: Incorporated as a monomer or modifier to create specialty fluoropolymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Organic Electronics: Building block for electron-transport materials (ETMs) and emitters in organic light-emitting diodes (OLEDs) and perovskite solar cells.
• Chemical Research: A versatile reagent for medicinal chemistry and process chemistry, enabling structure-activity relationship (SAR) studies and route scouting.

Basic Information

Product Name	2-(4-Chloro-3-Fluorophenyl)-2,2-Difluoroethan-1-Ol
CAS No.	1823848-47-0
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	2-(4-Chloro-3-fluorophenyl)-2,2-difluoroethanol; 1-(4-Chloro-3-fluorophenyl)-2,2-difluoroethan-1-ol; 4-Chloro-3-fluoro-α,α-difluorobenzeneethanol; 2,2-Difluoro-2-(4-chloro-3-fluorophenyl)ethanol; (4-Chloro-3-fluorophenyl)difluoromethyl carbinol
EINECS	Contact for details

Quality Control

Our production of 2-(4-Chloro-3-Fluorophenyl)-2,2-Difluoroethan-1-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for sensitive synthetic applications. All materials are subjected to comprehensive analytical characterization, including HPLC, GC, NMR, and MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider an inert atmosphere to preserve optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.