Description

2-(Benzyloxy)-4,5-Difluorobenzaldehyde is a high-purity fluorinated benzaldehyde derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in the strategic placement of fluorine atoms and a protected benzyloxy group, which are essential for modulating the electronic and steric properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the difluoro motif enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors and liquid crystals for electronic displays.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific fluorinated aromatic architectures.
• Academic and Industrial R&D: Used in research laboratories for method development and exploring new chemical reactions involving fluorinated aromatics.

Basic Information

Product Name	2-(Benzyloxy)-4,5-Difluorobenzaldehyde
CAS No.	1823269-78-8
Molecular Formula	C14H10F2O2
Molecular Weight	248.23 g/mol
Synonyms	4,5-Difluoro-2-(phenylmethoxy)benzaldehyde; Benzaldehyde, 2-(benzyloxy)-4,5-difluoro-; 4,5-Difluoro-2-(benzyloxy)benzaldehyde; 2-(Benzyloxy)-4,5-difluorobenzenecarboxaldehyde; 2-(Benzyloxy)-4,5-difluoro-1-benzaldehyde; 2-(Benzyloxy)-4,5-difluorobenzaldehyde (CAS 1823269-78-8)
EINECS	Contact for details

Quality Control

Our 2-(Benzyloxy)-4,5-Difluorobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider packaging under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.