Description

tert-Butyl 4-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-5-Amino-5-Oxopentanoate CAS NO 1822490-77-6 is a high-purity, protected amino acid derivative designed for advanced organic synthesis. This compound is a critical building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, offering precise control over molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including peptide-based drugs and targeted bioconjugates.

Application

• Peptide Synthesis Intermediate: A key protected intermediate for the controlled elongation of peptide chains in both Fmoc and Boc-based synthesis strategies.
• Pharmaceutical Research & Development: Serves as a crucial building block in the discovery and development of peptide therapeutics, hormone analogs, and enzyme inhibitors.
• Bioconjugation Chemistry: Used to introduce specific, protected functional handles onto biomolecules for the creation of antibody-drug conjugates (ADCs) or diagnostic probes.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery campaigns.
• Chemical Biology Probes: Facilitates the synthesis of labeled or modified peptides used to study protein-protein interactions and cellular pathways.
• Custom Oligomer Production: Essential for the manufacture of custom, non-natural amino acid sequences for specialized research and diagnostic applications.

Basic Information

Product Name	tert-Butyl 4-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-5-Amino-5-Oxopentanoate
CAS No.	1822490-77-6
Molecular Formula	C24H28N2O5
Molecular Weight	424.49 g/mol
Synonyms	Fmoc-Gln(OtBu)-OH; Nα-Fmoc-Nγ-trityl-L-glutamine; Fmoc-Glutamine(OtBu); 4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-5-amino-5-oxopentanoic acid tert-butyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine 1-tert-butyl ester; Fmoc-L-Gln-OtBu; Nα-Fmoc-Nγ-tritylglutamine 1-tert-butyl ester; Fmoc-Gln(Trt)-OtBu (common related protected form)
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, IR, MS), to ensure consistency and reliability for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredient (API) starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere (argon or nitrogen) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.