Description

3-Azetidinepropanoic Acid, 1-[(1,1-Dimethylethoxy)Carbonyl]-α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is a sophisticated, multi-protected amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is critical for constructing complex molecular architectures where precise stereochemistry and orthogonal protecting group strategies are required. It serves as a key building block for pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers developing novel therapeutic agents, particularly in the fields of oncology and metabolic diseases.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected azetidine-containing amino acid for the controlled incorporation of constrained ring systems into peptide chains.
• Medicinal Chemistry & Drug Discovery: A crucial intermediate for synthesizing peptide mimetics and small molecule drug candidates targeting specific protein-protein interactions.
• Chemical Biology Research: Used in the study of enzyme mechanisms and the development of activity-based probes due to its reactive azetidine scaffold.
• Pharmaceutical Intermediate: Serves as a high-value precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) with improved metabolic stability.
• Constrained Amino Acid Analogue Production: Enables the synthesis of peptides with restricted conformational flexibility to enhance binding affinity and selectivity.

Basic Information

Item	Details
Product Name	3-Azetidinepropanoic Acid, 1-[(1,1-Dimethylethoxy)Carbonyl]-α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)-
CAS No.	1821810-82-5
Molecular Formula	C26H30N2O6
Molecular Weight	466.53 g/mol
Synonyms	Fmoc-Aze(3)-OH(Boc); (S)-1-Boc-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)azetidine-3-carboxylic acid; Boc-Aze(3)-OH(Fmoc); Fmoc-3-amino-azetidine-3-carboxylic acid(Boc); 1-(tert-Butoxycarbonyl)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]azetidine-3-carboxylic acid; (αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1-[(1,1-dimethylethoxy)carbonyl]-3-azetidinepropanoic acid; Protected 3-Azetidinecarboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Every batch of this advanced building block is produced under strict quality control protocols to ensure the highest standards of purity and stereochemical integrity. Our products undergo rigorous testing, including chiral HPLC analysis, to confirm identity and assay purity typically exceeding 98%. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your GMP or research documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to decomposition. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.