Description

3-Cyclopropyl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). Its core value lies in enabling the precise and efficient construction of complex peptides containing cyclopropylglycine, a non-proteinogenic amino acid that introduces conformational constraints to enhance peptide stability and biological activity. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and fine chemical synthesis who require reliable, high-quality reagents for developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid, it is used in the automated, stepwise assembly of peptide chains on resin supports.
• Pharmaceutical Research & Development: Serves as a crucial intermediate for synthesizing peptide-based drug candidates, particularly those requiring cyclopropylglycine residues for metabolic stability and receptor selectivity.
• Bioconjugation and Peptide Labeling: The carboxylic acid moiety allows for further functionalization and conjugation to other molecules, carriers, or fluorescent tags.
• Production of Peptidomimetics: Used to create analogs of natural peptides with improved pharmacological properties, such as enhanced oral bioavailability and protease resistance.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of peptide-like compounds for high-throughput screening against biological targets.
• Academic and Institutional Research: Supports fundamental studies in peptide chemistry, structure-activity relationships (SAR), and medicinal chemistry.

Basic Information

Product Name	3-Cyclopropyl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid
CAS No.	1821775-85-2
Molecular Formula	C21H21NO4
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-Cpg-OH; Fmoc-1-Amino-1-cyclopropanecarboxylic Acid; Fmoc-(1-Amino-1-cyclopropyl)carboxylic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-amino-1-cyclopropanecarboxylic Acid; Nα-Fmoc-1-amino-1-cyclopropanecarboxylic Acid; (1-(((9H-Fluoren-9-yl)methoxy)carbonylamino)cyclopropyl)carboxylic Acid; Fmoc-cyclopropylglycine; Fmoc-Cyclopropyl-Gly-OH
EINECS	Contact for details

Quality Control

Our production of 3-Cyclopropyl-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive peptide synthesis applications. All materials undergo comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with each batch, documenting specifications for identity, assay, and impurity profiles. Our quality systems are designed to support cGMP-compliant manufacturing for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.