Description

Fmoc-o-Phenyl-L-Homoserine CAS NO 1821774-68-8 is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block, enabling the precise incorporation of a phenyl-substituted homoserine residue into peptide chains under standard Fmoc solid-phase peptide synthesis (SPPS) conditions. It is primarily required by research institutions, pharmaceutical developers, and biotechnology companies engaged in the discovery and production of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, used to introduce the o-phenyl-homoserine moiety into peptide sequences.
• Pharmaceutical Research & Development: Serves as a crucial intermediate in the synthesis of peptide-based drug candidates, particularly those targeting protein-protein interactions.
• Peptidomimetic Design: Used to create modified peptide structures with enhanced stability, bioavailability, or receptor binding affinity.
• Bioconjugation and Probe Synthesis: Facilitates the site-specific modification of peptides for labeling, imaging, or creating antibody-drug conjugates (ADCs).
• Chemical Biology Studies: Employed in the synthesis of tool compounds and substrates for studying enzyme mechanisms and cellular pathways.
• Academic Research: Used in university and institutional labs for fundamental studies in organic chemistry, medicinal chemistry, and peptide science.

Basic Information

Product Name	Fmoc-o-Phenyl-L-Homoserine
CAS No.	1821774-68-8
Molecular Formula	C25H23NO5
Molecular Weight	417.45 g/mol
Synonyms	Fmoc-O-(phenyl)-L-homoserine; (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-(phenoxy)butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-phenyl-L-homoserine; Fmoc-L-Homoserine(O-phenyl); Fmoc-Hse(Ph)-OH; N-α-Fmoc-O-phenyl-L-homoserine; L-Homoserine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-phenyl ether
EINECS	Contact for details

Quality Control

Our Fmoc-o-Phenyl-L-Homoserine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to meet exacting customer specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.