Description

5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-2-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is a critical building block in medicinal chemistry, valued for its role as a key scaffold in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers focused on developing kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold in the research and development of new drug candidates, particularly in oncology and CNS disorders.
• Kinase Inhibitor Synthesis: A key precursor for the synthesis of potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs in academic and industrial labs.
• Biochemical Tool Compound: Employed in biochemical assays and high-throughput screening to study enzyme function and identify new therapeutic targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and APIs.

Basic Information

Product Name	5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-2-Amine Dihydrochloride
CAS No.	1820703-96-5
Molecular Formula	C7H12Cl2N4
Molecular Weight	223.11 g/mol
Synonyms	2-Amino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine dihydrochloride; 5,6,7,8-Tetrahydro-2-pyrido[3,4-d]pyrimidinamine dihydrochloride; THPP-2-Amine dihydrochloride; Pyrido[3,4-d]pyrimidin-2-amine, 5,6,7,8-tetrahydro-, dihydrochloride; 1820703-96-5; 2-Amino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidin-2-Amine Dihydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.