Description

4-Ethoxyquinazoline-6-Carbonitrile CAS NO 1818847-80-1 is a high-purity, advanced pharmaceutical intermediate characterized by its distinct quinazoline core structure. This compound is of significant value for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical companies, contract research organizations (CROs), and academic research institutions focused on oncology, kinase inhibitors, and other targeted therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Building Block: Employed in the construction of more complex heterocyclic compounds due to its reactive nitrile and ethoxy functional groups.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4-Ethoxyquinazoline-6-Carbonitrile
CAS No.	1818847-80-1
Molecular Formula	C11H9N3O
Molecular Weight	199.21 g/mol
Synonyms	6-Cyano-4-ethoxyquinazoline; 4-Ethoxy-6-quinazolinecarbonitrile; Quinazoline-6-carbonitrile, 4-ethoxy-; 1818847-80-1; 4-Ethoxyquinazoline-6-CN
EINECS	Contact for details

Quality Control

Our 4-Ethoxyquinazoline-6-Carbonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.