Description

Cortistatin-29 (Rat) (Trifluoroacetate Salt) is a synthetic peptide analog of the endogenous neuropeptide cortistatin, specifically the rat sequence, and is supplied as a trifluoroacetate salt to enhance stability and solubility. This compound is a critical research tool for investigating the somatostatin receptor family, particularly its role in neural modulation, sleep regulation, and inflammatory processes. It is essential for neuroscientists, pharmacologists, and drug discovery teams in academic, pharmaceutical, and biotechnology sectors globally.

Application

• Neuroscience Research: Used as a selective ligand to study the function and distribution of somatostatin receptors (sst1-5) in the central and peripheral nervous systems.
• Sleep & Circadian Rhythm Studies: Investigates the role of cortistatin in slow-wave sleep induction and its interactions with other neuropeptides.
• Inflammatory & Immune Response Models: Applied in research exploring the anti-inflammatory and immunomodulatory effects of cortistatin signaling pathways.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool for screening and validating novel therapeutics targeting somatostatin receptors.
• Biochemical Assay Development: Utilized in receptor binding assays, functional cellular assays (e.g., cAMP inhibition), and antibody validation.
• Academic & Preclinical Studies: Supports fundamental research into neuroendocrine regulation, metabolic disorders, and potential therapeutic applications.

Basic Information

Product Name	Cortistatin-29 (Rat) (Trifluoroacetate Salt)
CAS No.	1815618-17-7
Molecular Formula	C₁₄₀H₂₂₈N₄₈O₄₀S • xC₂HF₃O₂
Molecular Weight	~3170.6 g/mol (free base)
Synonyms	Cortistatin-29, rat; CST-29; Cortistatin (1-29), rat; H-Phe-Pro-Lys-Pro-Asn-Ala-Pro-Arg-Gly-Arg-Arg-Lys-Glu-Arg-Leu-Leu-Gln-Lys-Leu-Leu-Gln-Ala-Asn-Gly-Asn-Leu-Ala-Thr-NH2 (TFA salt); Somatostatin-related peptide; Neuropeptide CST-29
EINECS	Contact for details

Quality Control

Our Cortistatin-29 (Rat) (Trifluoroacetate Salt) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC for purity, MS for identity, and other relevant assays. We support research requiring traceable, high-integrity biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Solubility	Soluble in water or aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.