Description

Biotinyl-Atrial Natriuretic Factor (1-28) (Human) CAS NO 1815618-06-4 is a biotinylated derivative of the bioactive N-terminal fragment of human atrial natriuretic peptide (ANP). This modification is critical for research and diagnostic applications, as the biotin tag enables highly sensitive detection, purification, and quantification via streptavidin-biotin interaction. This high-purity peptide is essential for scientists and manufacturers in the fields of cardiovascular research, immunoassay development, and biomarker discovery, where precise molecular targeting is required.

Application

• Biochemical Research: Used as a labeled tracer or probe in studies investigating the ANP receptor (NPR-A) signaling pathway, natriuresis, and blood pressure regulation.
• Diagnostic Kit Development: Serves as a critical component (antigen or labeled competitor) in the development of ELISA and other immunoassays for measuring ANP levels in clinical samples.
• Affinity Purification: The biotin tag allows for efficient immobilization on streptavidin-coated surfaces for the purification of specific antibodies or receptor proteins.
• Cell Biology Studies: Employed in fluorescence microscopy or flow cytometry applications to visualize receptor localization and internalization.
• Pharmaceutical Screening: Acts as a tool compound in high-throughput screening assays to identify novel modulators of the natriuretic peptide system.
• Reference Standard: Provides a well-characterized, high-purity standard for quality control in peptide synthesis and diagnostic manufacturing.

Basic Information

Product Name	Biotinyl-Atrial Natriuretic Factor (1-28) (Human)
CAS No.	1815618-06-4
Molecular Formula	C148H244N50O46S
Molecular Weight	~3328.9 g/mol
Synonyms	Biotin-ANP (1-28), Human; Biotinyl-ANP (1-28); Biotinylated Atrial Natriuretic Peptide (1-28); ANP (1-28), Biotinylated; Biotin-Atriopeptin (1-28); N-Biotinyl-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23); Biotin-SLRRSSSCFGGRIDRIGAQSGLGCNSFRY
EINECS	Contact for details

Quality Control

Our Biotinyl-ANP (1-28) (Human) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. We adhere to standards suitable for research and in-vitro diagnostic use, ensuring reliable performance in sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.