Description

Acetyl-Acth (4-24) (Human, Bovine, Rat) is a synthetic peptide fragment of adrenocorticotropic hormone (ACTH) that has been acetylated at the N-terminus. This modification is critical for enhancing its stability and biological activity in research applications, particularly in studies of the hypothalamic-pituitary-adrenal (HPA) axis. It is an essential biochemical tool for researchers and pharmaceutical developers in endocrinology, neuroscience, and drug discovery. The compound is supplied with a high level of purity and batch-to-batch consistency to ensure reliable experimental results.

Application

• Endocrine Research: Used as a specific ligand to study ACTH receptor binding, signal transduction, and steroidogenesis in adrenal cortex cells.
• Neuroscience Studies: Applied in investigations of stress response, behavioral models, and the central effects of ACTH fragments.
• Biochemical Assay Development: Serves as a reference standard or active component in immunoassays (ELISA, RIA) and functional cell-based assays.
• Pharmaceutical R&D: Utilized in the screening and development of novel therapeutics targeting the melanocortin system for metabolic and inflammatory disorders.
• Veterinary Research: Employed in comparative endocrinology studies across species, including bovine and rat models.
• Academic & Institutional Research: A key reagent for fundamental research into peptide hormone structure, function, and metabolism.

Basic Information

Product Name	Acetyl-Acth (4-24) (Human, Bovine, Rat)
CAS No.	1815618-00-8
Molecular Formula	C140H210N40O39S
Molecular Weight	3133.5 g/mol (theoretical)
Synonyms	Acetyl-ACTH (4-24); N-Acetyl-Adrenocorticotropic Hormone (4-24); Ac-ACTH (4-24); Acetylated ACTH Fragment 4-24; N-Ac-ACTH (4-24); Acetyl-Corticotropin (4-24); Acetyl-MSH/ACTH (4-24) Hybrid Fragment; [Acetyl]-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
EINECS	Contact for details

Quality Control

Every batch of Acetyl-Acth (4-24) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and peptide content. Our quality commitment includes providing a comprehensive Certificate of Analysis (COA) with each shipment, detailing results from HPLC, MS, and amino acid analysis. We support research standards and can provide material suitable for use as a reference compound.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum confirms molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.