Description

(Des-Glu)-Acth (1-24) (Human, Bovine, Rat) is a synthetic peptide fragment of the adrenocorticotropic hormone (ACTH) with the glutamic acid residue removed from the N-terminus. This modification is critical for research into the structure-activity relationships of ACTH and its receptor binding mechanisms. It is an essential biochemical tool for pharmaceutical R&D, academic research, and diagnostic development in endocrinology and metabolic disorders.

Application

• Biochemical and Pharmacological Research: Used as a key reference standard and active agent in studies investigating ACTH receptor (MC2R) signaling, steroidogenesis, and adrenal cortex function.
• Pharmaceutical Development: Serves as a critical intermediate and model compound in the development of novel peptide-based therapeutics targeting metabolic and stress-related pathways.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to measure ACTH levels in clinical and research settings.
• Academic Studies: Facilitates fundamental research in endocrinology, neurobiology, and physiology to understand the role of ACTH fragments in biological systems.
• Quality Control & Standardization: Acts as a high-purity standard for quality control in the production of related peptide hormones and diagnostic kits.

Basic Information

Product Name	(Des-Glu)-Acth (1-24) (Human, Bovine, Rat)
CAS No.	1815617-95-8
Molecular Formula	C₁₃₆H₂₁₀N₄₀O₃₉S
Molecular Weight	2933.4 g/mol
Synonyms	ACTH (1-24), Des-Glu¹-ACTH (1-24); Adrenocorticotropic Hormone Fragment 1-24 (Des-Glu¹); Corticotropin (1-24), De-Glutamyl; Norleu-ACTH (1-24); Tetracosactide (Des-Glu¹); Cosyntropin derivative; ACTH-(1-24)-amide (human, bovine, rat); [Des-Glu¹]-ACTH
EINECS	Contact for details

Quality Control

Our (Des-Glu)-Acth (1-24) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for peptide synthesis and can provide material traceable to recognized standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Assay (Content)	≥ 97.0% (on anhydrous basis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.