Description

Thieno[2,3-D]Pyrimidine-6-Carboxamide, 4-[[4-Fluoro-2-(1-Methylethoxy)Phenyl]Amino]-n-(2-Methoxyethyl)-5-Methyl- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in the creation of targeted small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of innovative drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Kinase Inhibitor Research: Serves as a core scaffold in the development of potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization processes to improve drug efficacy and safety profiles.
• Preclinical Development: Employed in the production of compounds for pharmacological, pharmacokinetic, and toxicological studies.
• Chemical Biology Probes: Utilized to create tool compounds for investigating specific biological targets and mechanisms of action.
• Custom Synthesis: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	Thieno[2,3-D]Pyrimidine-6-Carboxamide, 4-[[4-Fluoro-2-(1-Methylethoxy)Phenyl]Amino]-n-(2-Methoxyethyl)-5-Methyl-
CAS No.	1812885-57-6
Molecular Formula	C20H25FN4O3S
Molecular Weight	420.50 g/mol
Synonyms	4-((4-Fluoro-2-isopropoxyphenyl)amino)-N-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxamide; 4-[[4-Fluoro-2-(1-Methylethoxy)Phenyl]Amino]-5-Methyl-N-(2-Methoxyethyl)Thieno[2,3-d]Pyrimidine-6-Carboxamide; UNII-7W1J4F9V2I; 7W1J4F9V2I; Thienopyrimidine Carboxamide Derivative; BDBM50391485; AKOS025310889; AS-76311
EINECS	Contact for details

Quality Control

Our Thieno[2,3-D]Pyrimidine-6-Carboxamide intermediate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and pre-clinical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment. We support development under cGMP guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.