Description

Ethyl 4-(3-Bromo-4-Chlorophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS number 1809161-52-1. This compound is a key building block in the synthesis of complex heterocyclic molecules, offering critical structural features for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities within the dihydropyrimidinone (DHPM) scaffold, known for diverse biological activities.
• Agrochemical Development: Acts as a key intermediate for creating novel pesticides or herbicides, leveraging its halogenated aromatic and heterocyclic structure.
• Chemical Biology Probe Synthesis: Employed in the construction of molecular probes for studying enzyme mechanisms or protein-ligand interactions in biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions for clinical trial materials.
• Academic Research: Used in university and institutional laboratories for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Ethyl 4-(3-Bromo-4-Chlorophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	1809161-52-1
Molecular Formula	C14H14BrClN2O3
Molecular Weight	373.63 g/mol
Synonyms	4-(3-Bromo-4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; Ethyl 4-(3-bromo-4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidine-5-carboxylate; 5-Carbethoxy-4-(3-bromo-4-chlorophenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one; Biginelli Adduct Derivative; DHPM Derivative; 1809161-52-1; 4-(3-Bromo-4-chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-(3-Bromo-4-Chlorophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.