Description

Ethyl 4-(4-Fluoro-3-Methylthiophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS number 1809161-47-4. This compound is a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its precise molecular structure and functional groups. It is primarily required by R&D and production teams in the pharmaceutical and agrochemical industries for developing novel therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel dihydropyrimidinone (DHPM) based APIs, which are a class of compounds with diverse biological activities.
• Medicinal Chemistry Research: Used as a scaffold for drug discovery programs targeting various diseases, leveraging its tetrahydropyrimidine core.
• Agrochemical Synthesis: Serves as a key intermediate in the development of new-generation pesticides and herbicides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production under cGMP guidelines.

Basic Information

Item	Detail
Product Name	Ethyl 4-(4-Fluoro-3-Methylthiophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	1809161-47-4
Molecular Formula	C15H17FN2O3S
Molecular Weight	324.37 g/mol
Synonyms	4-(4-Fluoro-3-methylthiophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; Ethyl 4-(4-fluoro-3-(methylthio)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 1,2,3,4-Tetrahydropyrimidine-5-carboxylic acid, 4-(4-fluoro-3-(methylthio)phenyl)-6-methyl-2-oxo-, ethyl ester; DHPM derivative; Biginelli reaction product
EINECS	Contact for details

Quality Control

Our Ethyl 4-(4-Fluoro-3-Methylthiophenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment supports applications requiring high standards, including pharmaceutical R&D under potential cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.