Description

Ethyl 4-(5-Fluoro-3-Methoxyphenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology industries engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale production for clinical trial material (CTM) manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global pharmaceutical development pipelines.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and novel synthetic methodologies.
• Chemical Library Synthesis: A valuable component for creating diverse screening libraries for high-throughput biological testing.

Basic Information

Product Name	Ethyl 4-(5-Fluoro-3-Methoxyphenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	1809157-85-4
Molecular Formula	C15H17FN2O4
Molecular Weight	308.31 g/mol
Synonyms	Ethyl 4-(5-fluoro-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbethoxy-4-(5-fluoro-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one; 1,2,3,4-Tetrahydropyrimidine-5-carboxylic acid, 4-(5-fluoro-3-methoxyphenyl)-6-methyl-2-oxo-, ethyl ester; 1809157-85-4; DHPM derivative; Fluorinated dihydropyrimidinone ester.
EINECS	Contact for details

Quality Control

Our Ethyl 4-(5-Fluoro-3-Methoxyphenyl)-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.