Description

n-Fmoc-7-Methyl-L-Tryptophan CAS NO 1808268-53-2 is a protected, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing modified tryptophan residues into peptide chains, enabling the development of novel bioactive molecules with enhanced stability and targeted functionality. It is an essential building block for pharmaceutical researchers and peptide chemists working in drug discovery, proteomics, and the development of therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the controlled incorporation of 7-methyltryptophan into peptide sequences.
• Drug Discovery & Medicinal Chemistry: Used to synthesize peptide-based drug candidates and libraries for screening against various biological targets, particularly where tryptophan modification is required.
• Peptidomimetic Development: Serves as a precursor for creating stable peptide analogs with improved pharmacokinetic properties, such as enhanced metabolic stability and membrane permeability.
• Bioconjugation & Probe Synthesis: Enables the site-specific labeling of peptides with fluorophores, affinity tags, or other functional groups for diagnostic and research applications.
• Academic & Industrial Research: A fundamental reagent for studying protein-protein interactions, enzyme specificity, and structure-activity relationships (SAR) in academic and R&D laboratories.

Basic Information

Product Name	n-Fmoc-7-Methyl-L-Tryptophan
CAS No.	1808268-53-2
Molecular Formula	C28H26N2O4
Molecular Weight	454.52 g/mol
Synonyms	Fmoc-7-Me-Trp-OH; Fmoc-7-methyltryptophan; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-7-methyl-L-tryptophan; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(7-methyl-1H-indol-3-yl)propanoic acid; 7-Methyl-L-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-Fmoc-7-methyl-L-tryptophan; Fmoc-7-methyl-L-Trp; Fmoc-7-methyl-L-Trp-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-7-Methyl-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for sensitive peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, batch-to-batch consistency, and compliance with relevant research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.