Description

Fmoc-Phe(4-Cf2H)-Oh is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is engineered to introduce a unique difluoromethyl group at the para position of the phenylalanine side chain, enabling precise modulation of peptide properties such as lipophilicity, metabolic stability, and binding affinity. It is an essential building block for medicinal chemists and researchers in pharmaceutical R&D, biotechnology, and academic institutions developing novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the construction of complex peptides with site-specific fluorination.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide analogs and peptidomimetics to explore structure-activity relationships (SAR) and improve drug-like properties.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorinated peptide tags and probes for imaging (e.g., PET) or biochemical assays.
• Chemical Biology Research: Enables the study of protein-protein interactions and enzyme mechanisms by incorporating a stable fluorine handle into peptide sequences.
• Pharmaceutical Intermediate: A critical raw material in the development and cGMP production of fluorinated active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-Phe(4-Cf2H)-Oh
CAS No.	1808268-08-7
Molecular Formula	C25H21F2NO4
Molecular Weight	437.44 g/mol
Synonyms	Fmoc-4-(difluoromethyl)-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(difluoromethyl)-L-phenylalanine; Fmoc-L-Phe(4-CF2H)-OH; N-α-Fmoc-4-(difluoromethyl)-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-[4-(difluoromethyl)phenyl]propanoic acid; Fmoc-4-(difluoromethyl)Phe-OH; Fmoc-Difluoromethylphenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-Phe(4-Cf2H)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed specifications are provided to ensure the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.