Description

4-Chloro-2,3-Difluorobenzyl Bromide is a high-value, multi-functional halogenated benzyl bromide building block. This compound is essential for introducing the 4-chloro-2,3-difluorobenzyl moiety into complex molecular architectures, enabling precise structural modifications. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro and chloro substituents modulate biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile starting material for constructing specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized monomers for advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Acts as an electrophilic partner in Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution Scaffold: The benzyl bromide group is highly reactive towards nucleophiles, facilitating the introduction of amines, thiols, and alkoxides.

Basic Information

Product Name	4-Chloro-2,3-Difluorobenzyl Bromide
CAS No.	1807217-14-6
Molecular Formula	C7H4BrClF2
Molecular Weight	241.46 g/mol
Synonyms	1-(Bromomethyl)-4-chloro-2,3-difluorobenzene; (4-Chloro-2,3-difluorophenyl)methyl Bromide; 2,3-Difluoro-4-chlorobenzyl Bromide; α-Bromo-4-chloro-2,3-difluorotoluene; 4-Chloro-2,3-difluoro-α-bromotoluene; Benzene, 1-(bromomethyl)-4-chloro-2,3-difluoro-; 4-Chloro-2,3-difluorobenzylbromide
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2,3-Difluorobenzyl Bromide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. Handle and store under an inert atmosphere if prolonged storage is required to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.