Description

4-Pyrimidinecarboxylic Acid, 5-(Trifluoromethyl)-, Ethyl Ester is a high-value fluorinated pyrimidine derivative, a crucial building block in modern synthetic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique physicochemical properties essential for developing advanced materials and bioactive molecules. This compound is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for advanced organic materials, including liquid crystals, organic semiconductors, and polymers with tailored electronic properties.
• Chemical Biology Probe: Employed in medicinal chemistry to create molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Pyrimidinecarboxylic Acid, 5-(Trifluoromethyl)-, Ethyl Ester
CAS No.	1806545-85-6
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	Ethyl 5-(Trifluoromethyl)pyrimidine-4-carboxylate; 5-(Trifluoromethyl)pyrimidine-4-carboxylic Acid Ethyl Ester; 4-Carbethoxy-5-trifluoromethylpyrimidine; Ethyl 5-Trifluoromethyl-4-pyrimidinecarboxylate; 5-Trifluoromethyl-4-pyrimidinecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our 4-Pyrimidinecarboxylic Acid, 5-(Trifluoromethyl)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids/bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.