Description

3-Piperidinol, 4-[[[3-(1-Methylethyl)-7-[(Phenylmethyl)Amino]Pyrazolo[1,5-A]Pyrimidin-5-Yl]Amino]Methyl]-, Hydrochloride (1:1), (3R,4R)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted therapeutic agents. It is primarily required by pharmaceutical companies and advanced R&D facilities working on novel drug candidates, especially in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Oncology Drug Development: Serves as a precursor in the development of kinase inhibitors and other targeted anti-cancer agents.
• Preclinical & Clinical Trial Material: Supplied for the production of materials required for non-clinical studies and early-phase clinical trials.
• Process Chemistry & Scale-Up: Employed in route scouting and process development for efficient and scalable API manufacturing.
• Biochemical Research: Used as a tool compound to study specific biological pathways and enzyme interactions.

Basic Information

Product Name	3-Piperidinol, 4-[[[3-(1-Methylethyl)-7-[(Phenylmethyl)Amino]Pyrazolo[1,5-A]Pyrimidin-5-Yl]Amino]Methyl]-, Hydrochloride (1:1), (3R,4R)-
CAS No.	1805789-54-1
Molecular Formula	C23H31N7O • HCl
Molecular Weight	482.01 g/mol
Synonyms	(3R,4R)-4-[[[3-Isopropyl-7-(benzylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-3-piperidinol hydrochloride; (3R,4R)-4-({[3-Isopropyl-7-(benzylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino}methyl)piperidin-3-ol hydrochloride; (3R,4R)-4-(((3-Isopropyl-7-((phenylmethyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-ol hydrochloride; UNII-Contact for details; Advanced Pharmaceutical Intermediate 1805789-54-1; (R,R)-Isomer of 4-[[[3-(1-Methylethyl)-7-[(Phenylmethyl)Amino]Pyrazolo[1,5-A]Pyrimidin-5-Yl]Amino]Methyl]-3-piperidinol HCl
EINECS	Contact for details

Quality Control

Our 3-Piperidinol, 4-[[[3-(1-Methylethyl)-7-[(Phenylmethyl)Amino]Pyrazolo[1,5-A]Pyrimidin-5-Yl]Amino]Methyl]-, Hydrochloride (1:1), (3R,4R)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including chiral purity verification, to meet the exacting standards of pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (3R,4R)-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.