Description

2-Chloro-5-Fluoro-4-Trifluoromethyl-Phenylamine is a high-purity, multi-functional aromatic amine building block of significant importance in advanced organic synthesis. Its unique structure, featuring chloro, fluoro, and trifluoromethyl substituents, makes it a critical intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for creating complex, high-performance dyes and pigments with specific color fastness and solubility properties.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination, Suzuki-Miyaura) for constructing complex biaryl and heterocyclic systems.
• Chemical Research & Development: A valuable reagent for academic and industrial research in medicinal chemistry, process chemistry, and methodology development.

Basic Information

Product Name	2-Chloro-5-Fluoro-4-Trifluoromethyl-Phenylamine
CAS No.	1805524-30-4
Molecular Formula	C7H4ClF4N
Molecular Weight	213.56 g/mol
Synonyms	2-Chloro-5-fluoro-4-(trifluoromethyl)aniline; 4-Amino-2-chloro-5-fluoro-α,α,α-trifluorotoluene; 2-Chloro-α,α,α,5-tetrafluoro-p-toluidine; 2-Chloro-5-fluoro-4-trifluoromethylbenzenamine; 2-Chloro-5-fluoro-α,α,α-trifluoro-p-toluidine; Benzenamine, 2-chloro-5-fluoro-4-(trifluoromethyl)-; 2-Chloro-5-fluoro-4-(trifluoromethyl)phenylamine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-4-Trifluoromethyl-Phenylamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.