Description

5-Difluoromethoxy-2-(Trifluoromethyl)Aniline is a high-value fluorinated aniline derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethyl and difluoromethoxy substituents make it an essential intermediate for developing novel compounds with enhanced biological activity and physicochemical properties. This product is primarily targeted at the pharmaceutical and agrochemical research and development sectors, where it is used to create next-generation active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve metabolic stability and membrane permeability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorination patterns.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and affinity tags to study biological systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the life sciences industry.

Basic Information

Product Name	5-Difluoromethoxy-2-(Trifluoromethyl)Aniline
CAS No.	1804416-58-7
Molecular Formula	C8H6F5NO
Molecular Weight	227.13 g/mol
Synonyms	2-(Trifluoromethyl)-5-(difluoromethoxy)aniline; 5-(Difluoromethoxy)-2-(trifluoromethyl)benzenamine; 2-Amino-4-(difluoromethoxy)benzotrifluoride; Benzenamine, 5-(difluoromethoxy)-2-(trifluoromethyl)-; 1804416-58-7; 5-Difluoromethoxy-2-trifluoromethyl-aniline
EINECS	Contact for details

Quality Control

Our 5-Difluoromethoxy-2-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.