Description

3,4-Difluoro-5-(Trifluoromethyl)Aniline is a high-value, multi-fluorinated aniline derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoro and trifluoromethyl substituents, imparts significant electronic and steric properties that are highly sought after for modulating the activity and metabolic stability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced performance profiles.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, central nervous system (CNS), and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms improve lipophilicity and biological activity.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its ability to fine-tune electronic properties.
• Fluorinated Dye & Pigment Manufacturing: Acts as a starting material for creating advanced fluorinated colorants with superior stability and performance.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Buchwald-Hartwig amination) and nucleophilic aromatic substitution to introduce complex aniline motifs.

Basic Information

Product Name	3,4-Difluoro-5-(Trifluoromethyl)Aniline
CAS No.	1803790-37-5
Molecular Formula	C7H4F5N
Molecular Weight	197.11 g/mol
Synonyms	5-(Trifluoromethyl)-3,4-difluoroaniline; 3,4-Difluoro-5-(trifluoromethyl)benzenamine; 2,3-Difluoro-6-(trifluoromethyl)aniline; 1-Amino-3,4-difluoro-5-(trifluoromethyl)benzene; Benzenamine, 3,4-difluoro-5-(trifluoromethyl)-; 3,4-Difluoro-5-trifluoromethylaniline; 3,4-DFA-TFMA
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-5-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.