Description

(3-Fluoropyrrolidin-3-Yl)Methanol Hydrochloride is a high-purity fluorinated pyrrolidine derivative, a crucial building block in modern pharmaceutical and agrochemical research. This compound matters because its unique structure, featuring a fluorinated heterocycle with a hydroxymethyl group, is essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule therapeutics, especially protease inhibitors and kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms and chiral centers into lead compounds.
• Agrochemical Synthesis: Serves as a precursor in the creation of advanced pesticides and herbicides with enhanced efficacy and environmental profile.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-up: Employed in the optimization and commercial-scale production of active pharmaceutical ingredients (APIs).
• Chiral Building Block: Provides a versatile, enantiomerically enriched scaffold for asymmetric synthesis.

Basic Information

Product Name	(3-Fluoropyrrolidin-3-Yl)Methanol Hydrochloride
CAS No.	1803611-93-9
Molecular Formula	C5H11ClFNO
Molecular Weight	155.60 g/mol
Synonyms	3-(Hydroxymethyl)-3-fluoropyrrolidine hydrochloride; (3-Fluoro-3-pyrrolidinyl)methanol hydrochloride; 3-Fluoro-3-pyrrolidinemethanol hydrochloride; 3-Fluoropyrrolidine-3-methanol HCl; 3-Fluoro-3-(hydroxymethyl)pyrrolidine hydrochloride; 3-Fluoropyrrolidin-3-ylmethanol hydrochloride; (3R)-3-Fluoropyrrolidin-3-ylmethanol hydrochloride (for enantiopure form); (3S)-3-Fluoropyrrolidin-3-ylmethanol hydrochloride (for enantiopure form)
EINECS	Contact for details

Quality Control

Our (3-Fluoropyrrolidin-3-Yl)Methanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and consistent chiral integrity where applicable. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Chiral Purity (Chiral HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.