Description

Ethyl 5-(((R)-1-(2-(((S)-1-((tert-Butoxycarbonyl)Amino)Propan-2-Yl)Oxy)-5-Fluorophenyl)Ethyl)Amino)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate is a sophisticated, stereochemically defined pyrazolopyrimidine derivative, serving as a critical advanced pharmaceutical intermediate. This compound is essential for the research and development of targeted therapeutic agents, particularly in oncology and kinase inhibition pathways. It is primarily utilized by pharmaceutical R&D teams, process chemists, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of novel, high-potency active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex drug candidates, particularly kinase inhibitors.
• Oncology Research: Used in the discovery and development of targeted cancer therapies due to its pyrazolo[1,5-a]pyrimidine core structure.
• Kinase Inhibitor Synthesis: Serves as a precursor for compounds designed to modulate specific kinase activity in biochemical pathways.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and cGMP manufacturing for clinical trial material.
• Chemical Biology: Utilized as a molecular probe to study enzyme function and cellular signaling mechanisms.
• Custom Synthesis: A starting material for the preparation of analogs and derivatives in medicinal chemistry programs.

Basic Information

Product Name	Ethyl 5-(((R)-1-(2-(((S)-1-((tert-Butoxycarbonyl)Amino)Propan-2-Yl)Oxy)-5-Fluorophenyl)Ethyl)Amino)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate
CAS No.	1802222-30-5
Molecular Formula	C26H33FN6O5
Molecular Weight	528.58 g/mol
Synonyms	Ethyl 5-{[(1R)-1-{2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}propoxy]-5-fluorophenyl}ethyl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxylate; BOC-Protected Pyrazolopyrimidine Intermediate; (R,S)-Boc-Pyrazolopyrimidine Ester; 5-Aminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester derivative; CAS 1802222-30-5; FC-AD-201/1802222-30-5; Advanced Kinase Inhibitor Intermediate.
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to confirm stereochemical purity, HPLC assay for chemical purity, and identification by NMR and Mass Spectrometry. We provide full traceability and Certificates of Analysis (COA) detailing purity, impurities, and solvent residues, ensuring compliance with the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.