Description

(7-Diethylaminocoumarin-3-Yl)Carbonyl-Amyloid β-Protein (1-40) is a specialized fluorescently-labeled peptide derivative designed for advanced biochemical research. This compound matters as a critical tool for the sensitive detection, quantification, and imaging of amyloid-beta (Aβ) peptides, which are central to the study of neurodegenerative diseases. Researchers in pharmaceutical R&D, academic neuroscience, and diagnostic development need this high-purity reagent for applications such as fluorescence polarization assays, microscopy, and in vitro binding studies to elucidate disease mechanisms and screen potential therapeutics.

Application

• Fluorescence Polarization (FP) Assays: Used as a tracer to study the binding interactions of Aβ(1-40) with antibodies, inhibitors, or other biomolecules in high-throughput screening.
• Biomolecular Imaging: Enables visualization of amyloid-beta peptide aggregation, localization, and dynamics in cellular and tissue models using fluorescence microscopy.
• Binding Affinity Studies: Serves as a key reagent in surface plasmon resonance (SPR) or other biophysical techniques to determine binding kinetics and affinity constants.
• Diagnostic Assay Development: Acts as a core component in the development of sensitive in vitro diagnostic (IVD) tests for detecting amyloid-β-related biomarkers.
• Neurodegenerative Disease Research: Facilitates fundamental research into Alzheimer's disease pathology by providing a detectable probe for Aβ peptide behavior.
• Quality Control for Therapeutics: Used in the characterization and potency testing of antibody-based or other biologic therapies targeting amyloid-beta.

Basic Information

Product Name	(7-Diethylaminocoumarin-3-Yl)Carbonyl-Amyloid β-Protein (1-40)
CAS No.	1802087-66-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Aβ(1-40) Coumarin Conjugate; Amyloid Beta Protein (1-40) labeled with 7-Diethylaminocoumarin-3-carboxylic acid; Fluorescently-labeled Aβ40; Aβ40-Coumarin; Coumarin-Aβ(1-40); Amyloid-β (1-40) peptide, N-(7-(diethylamino)-2-oxo-2H-chromene-3-carbonyl)-; Aβ1-40-Coumarin; DABCYL-Aβ(1-40) (common alternative fluorophore type)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of (7-Diethylaminocoumarin-3-Yl)Carbonyl-Amyloid β-Protein (1-40) is characterized using advanced analytical techniques to confirm identity, purity, and labeling efficiency. Certificates of Analysis (COA) are available upon request, providing detailed results for parameters such as HPLC purity, mass spectrometry (MS) confirmation, and fluorophore-to-peptide ratio.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Fluorophore Incorporation	≥ 0.9 mol Coumarin / mol peptide
Solubility	Soluble in DMSO, DMF, or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.