Description

Biotinyl-Glucagon (1-29) (Human, Rat, Porcine) is a biotin-conjugated peptide fragment of the glucagon hormone, specifically designed for high-affinity detection and isolation applications. This modified peptide is critical for advanced research in metabolic pathways, enabling precise targeting and visualization in complex biological systems. It is an essential reagent for pharmaceutical R&D, diagnostic assay development, and academic research focused on diabetes, obesity, and liver function. The compound is supplied with a Certificate of Analysis to ensure batch-to-batch consistency and research reliability.

Application

• Biochemical Research: Used as a high-specificity probe for studying glucagon receptor binding, internalization, and downstream signaling cascades.
• Diagnostic Development: Serves as a critical capture or detection component in immunoassays (ELISA, Western Blot) for glucagon measurement.
• Affinity Purification: Employed in streptavidin/avidin-based pull-down assays to isolate and characterize glucagon-binding proteins or receptor complexes.
• Cell Imaging: Facilitates fluorescence or electron microscopy studies of glucagon localization and trafficking within cells when paired with labeled streptavidin.
• Drug Discovery: Acts as a tool compound for screening and validating novel therapeutics targeting the glucagon receptor for metabolic disorders.
• Peptide & Antibody Production: Functions as a standardized antigen for the generation and characterization of specific anti-glucagon antibodies.

Basic Information

Product Name	Biotinyl-Glucagon (1-29) (Human, Rat, Porcine)
CAS No.	1802086-28-7
Molecular Formula	C152H246N44O48S
Molecular Weight	3484.9 g/mol
Synonyms	Biotin-Glucagon (1-29); Biotinylated Glucagon; Glucagon (1-29), Biotin conjugate; Biotinyl-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr; Biotin-Glucagon Fragment 1-29; Biotin-GLP-1 related peptide; Biotin-Labeled Glucagon
EINECS	Contact for details

Quality Control

Every batch of Biotinyl-Glucagon (1-29) is manufactured and analyzed under strict quality protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade peptides. Certificates of Analysis (COA) are provided, detailing key parameters such as purity (by HPLC), molecular weight confirmation (by MS), and biotin incorporation ratio. We adhere to cGMP guidelines where applicable to support preclinical and diagnostic development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Biotin Incorporation	≥ 90% (by HPLC/ELISA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.