Description

(Glu13·17·20)-Osteocalcin (1-46) (Mouse) is a specific, post-translationally modified peptide fragment of mouse osteocalcin, a key non-collagenous protein involved in bone metabolism and endocrine regulation. This precisely defined sequence is critical for researchers investigating the role of carboxylated glutamic acid (Gla) residues in calcium binding, bone mineralization, and the hormone-like functions of osteocalcin. It is an essential biochemical tool for academic institutions, pharmaceutical R&D departments, and biotechnology companies focused on metabolic bone disease research, osteoporosis drug discovery, and studies of bone-energy metabolism crosstalk.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in mass spectrometry (MS) and chromatographic assays (HPLC) for the quantification and characterization of endogenous osteocalcin and its fragments.
• In Vitro Assay Development: Serves as a critical antigen or calibrator in the development and validation of immunoassays (ELISA, RIA) specific for the carboxylated forms of osteocalcin.
• Cell Signaling Studies: Applied in cell culture experiments to study the receptor-mediated effects of osteocalcin on pancreatic β-cells, adipocytes, and muscle cells, elucidating its role in glucose metabolism and energy expenditure.
• Bone Biology Research: Utilized to investigate osteocalcin's function in hydroxyapatite crystal formation, bone remodeling, and the differentiation of osteoblasts and osteoclasts in mouse models.
• Metabolic Disease Modeling: Essential for preclinical research aimed at understanding the pathophysiology of osteoporosis, diabetes, and obesity, and for screening potential therapeutic compounds.
• Antibody Production: Acts as an immunogen for generating highly specific polyclonal or monoclonal antibodies against carboxylated osteocalcin epitopes.

Basic Information

Item	Details
Product Name	(Glu13·17·20)-Osteocalcin (1-46) (Mouse)
CAS No.	1802086-27-6
Molecular Formula	C₂₂₉H₃₆₈N₆₈O₇₈
Molecular Weight	5175.9 g/mol (theoretical average)
Synonyms	Mouse Osteocalcin (1-46), γ-carboxyglutamic acid-containing; Mouse BGP (1-46); Carboxylated Mouse Osteocalcin Fragment 1-46; mOCN(1-46); Gla-type Osteocalcin (Mouse); Bone Gla Protein Fragment (Mouse); (Gla13,17,20)-mOCN(1-46)
EINECS	Contact for details

Quality Control

Our (Glu13·17·20)-Osteocalcin (1-46) (Mouse) is manufactured and controlled under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is characterized by advanced analytical techniques including reverse-phase HPLC, mass spectrometry (MS) for sequence confirmation and molecular weight verification, and amino acid analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and analytical data. Our quality system supports research requiring materials traceable to reliable standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Consistent with reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight (MS)	5175.9 ± 2.0 Da
Solubility	Soluble in water or dilute aqueous acid
Endotoxin Level	< 1.0 EU/µg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.