Description

Amyloid β/A4 Protein Precursor (740-770) is a synthetic peptide fragment corresponding to residues 740-770 of the human amyloid precursor protein (APP). This specific sequence is of significant research interest for its role in the formation and study of amyloid-beta peptides, which are central to Alzheimer's disease pathology. It serves as a critical biochemical tool for neuroscientists, pharmaceutical researchers, and diagnostic developers. The compound is supplied with high purity and batch-to-batch consistency, essential for reliable experimental outcomes.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta peptide generation, aggregation kinetics, and neurotoxicity.
• Drug Discovery & Development: Screening and validation of therapeutic candidates targeting APP processing and amyloid-beta production.
• Biomarker & Diagnostic Assay Development: Used as a reference standard or antigen in immunoassays (ELISA, Western Blot) to detect APP fragments or related antibodies.
• Biochemical Mechanism Studies: Investigating the enzymatic cleavage of APP by secretases (α, β, γ-secretase).
• Antibody Production: Immunogen for generating sequence-specific antibodies against the APP C-terminal region.
• In vitro Model Systems: Component in cell-free or cellular models designed to study Alzheimer's disease mechanisms.

Basic Information

Product Name	Amyloid β/A4 Protein Precursor (740-770)
CAS No.	1802086-24-3
Molecular Formula	C164H257N45O49S
Molecular Weight	~3670.2 g/mol
Synonyms	APP (740-770); Amyloid Beta A4 Protein Precursor (740-770); Amyloid Precursor Protein Fragment 740-770; AβPP (740-770); C-Terminal Fragment of APP (CTF); p3 Peptide Precursor Fragment; Alzheimer's Disease Amyloid Peptide Precursor Fragment; Synthetic APP Peptide
EINECS	Contact for details

Quality Control

Our Amyloid β/A4 Protein Precursor (740-770) is manufactured under stringent conditions to ensure the highest standards of purity and identity required for life science research. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, amino acid composition, and molecular weight verification. We adhere to rigorous quality testing protocols to guarantee batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Molecular Weight (MS)	3670.2 ± 2.0 Da
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.