Description

(Glu20)-Amyloid β-Protein (1-42) CAS NO 1802086-22-1 is a specific, chemically modified peptide variant of the amyloid-beta protein, a key molecule in neurological research. This product is essential for researchers investigating the molecular mechanisms of protein aggregation and its implications in neurodegenerative conditions. It is primarily utilized by pharmaceutical R&D teams, academic laboratories, and biotechnology companies focused on neuroscience, diagnostics, and therapeutic development.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta aggregation kinetics, fibril formation, and oligomer toxicity.
• Drug Discovery & Screening: Used as a target substrate in high-throughput assays to identify and validate potential inhibitors of amyloid aggregation.
• Biomarker Development: Serves as a critical reference standard in the development of immunoassays and diagnostic tools for detecting specific amyloid-beta isoforms.
• Therapeutic Antibody Testing: Acts as a key antigen for evaluating the binding affinity and specificity of candidate therapeutic antibodies.
• Structural Biology: Provides material for X-ray crystallography, NMR spectroscopy, and cryo-EM studies to elucidate protein structure and interaction sites.
• Cell Culture & Model Systems: Used to treat neuronal cell cultures or create animal models to study cellular toxicity and disease pathology.

Basic Information

Product Name	(Glu20)-Amyloid β-Protein (1-42)
CAS No.	1802086-22-1
Molecular Formula	C203H311N55O60S
Molecular Weight	4514.0 g/mol
Synonyms	Glu20-Aβ42; Aβ42 (E20); Amyloid β-Protein (1-42) (Glu20); Aβ (1-42) E20 variant; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (Glu20); Modified Amyloid-β (1-42); Asp1-Glu20-Aβ42; Research Peptide 1802086-22-1
EINECS	Contact for details

Quality Control

Every batch of (Glu20)-Amyloid β-Protein (1-42) is produced and analyzed under stringent conditions to ensure the highest standards of identity, purity, and consistency for research applications. Our quality commitment includes comprehensive characterization by HPLC, MS (Mass Spectrometry), and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming critical specifications such as purity, peptide content, and endotoxin levels.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. This product is hygroscopic (moisture-sensitive). Solutions should be prepared fresh in appropriate buffers and used immediately or aliquoted and stored at ≤ -70°C to minimize freeze-thaw cycles and degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Molecular Weight	4514.0 ± 2.0 Da (by MS)
Solubility	Soluble in DMSO or dilute basic aqueous solutions
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.