Description

Biotinyl-Amyloid β-Protein (1-42) is a biotin-conjugated, synthetic peptide fragment corresponding to the amyloid-beta protein, a key component in Alzheimer's disease research. This modified peptide is crucial for high-sensitivity detection and isolation assays, such as ELISA, Western blotting, and affinity purification, due to the strong biotin-streptavidin interaction. It is an essential research-grade biochemical for neuroscientists, pharmaceutical developers, and diagnostic manufacturers focused on neurodegenerative disease mechanisms and therapeutic target validation.

Application

• Biomarker Research & Assay Development: Used as a calibrated antigen in immunoassays (ELISA) to detect and quantify amyloid-beta levels in biological samples.
• Affinity Purification & Pull-Down Assays: The biotin tag enables efficient capture using streptavidin-coated beads for isolating interacting proteins or antibodies.
• Diagnostic Kit Manufacturing: Serves as a critical raw material in the production of in-vitro diagnostic (IVD) kits for Alzheimer's disease research.
• Therapeutic Antibody Screening: Acts as a target substrate for screening and characterizing monoclonal antibodies designed to bind amyloid-beta plaques.
• Neuroscience & Cell Biology Studies: Employed in cellular uptake studies, aggregation kinetics experiments, and neurotoxicity models.
• Quality Control & Standardization: Used as a reference standard to validate the performance and specificity of other reagents and assays within a laboratory.

Basic Information

Product Name	Biotinyl-Amyloid β-Protein (1-42)
CAS No.	1802086-20-9
Molecular Formula	C207H317N55O58S
Molecular Weight	4514.2 g/mol
Synonyms	Biotin-Aβ(1-42); Biotin-Amyloid Beta (1-42); Biotinylated Aβ42; Biotin-Aβ42; Biotin-conjugated Amyloid-β Protein (1-42); Biotinyl-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; N-Biotinylamyloid β-Protein (1-42) human; Aβ42-Biotin
EINECS	Contact for details

Quality Control

Our Biotinyl-Amyloid β-Protein (1-42) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to rigorous analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	4514.2 ± 2 Da (by MS)
Solvent Residues	Meets ICH guidelines
Biological Activity	Confirmed by binding assay (e.g., streptavidin-HRP)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.