Description

(D-Asp1)-Amyloid β-Protein (1-42) CAS NO 1802086-19-6 is a synthetic, site-specifically modified peptide variant of the amyloid-beta protein, a key molecule in Alzheimer's disease research. This compound matters as a critical tool for investigating the role of isomerization and post-translational modifications in amyloid aggregation, neurotoxicity, and disease pathology. It is primarily needed by pharmaceutical R&D teams, academic neuroscientists, and diagnostic developers focused on neurodegenerative disease mechanisms and therapeutic target validation.

Application

• Biochemical Research: Fundamental studies on the kinetics and thermodynamics of amyloid-beta aggregation and fibril formation.
• Drug Discovery & Screening: Used as a target substrate in high-throughput assays to identify and validate potential inhibitors of amyloid aggregation or toxicity.
• Antibody & Diagnostic Development: Serves as a specific antigen for generating and characterizing antibodies that distinguish between modified and native amyloid-beta isoforms.
• Neurotoxicity Studies: Application in cell-based (e.g., neuronal cell cultures) and in vivo models to assess the specific pathogenic contribution of the D-Asp1 modification.
• Structural Biology: Utilization in NMR, X-ray crystallography, or cryo-EM studies to determine the structural impact of the aspartate isomerization.
• Biomarker Research: Investigation of its presence and concentration in biological fluids as a potential diagnostic or prognostic marker for Alzheimer's disease.

Basic Information

Product Name	(D-Asp1)-Amyloid β-Protein (1-42)
CAS No.	1802086-19-6
Molecular Formula	C203H311N55O60S
Molecular Weight	4514.0 g/mol
Synonyms	D-Asp1-Amyloid β-Protein (1-42); Aβ42 (D-Asp1); Amyloid Beta Peptide (1-42) D-Aspartate Isomer; β-Amyloid (1-42), D-Asp1-; DAsp-Aβ(1-42); Aβ(1-42) with D-Asp at position 1; Alzheimer's Disease Amyloid Peptide Variant
EINECS	Contact for details

Quality Control

Our (D-Asp1)-Amyloid β-Protein (1-42) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is assured through a comprehensive analytical package including HPLC for purity, MS (Mass Spectrometry) for identity and molecular weight confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided with each batch to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Solubility	Soluble in dilute ammonium hydroxide or DMSO
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.